The trio of Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi have been awarded the Nobel Prize in Physiology or Medicine 2025.
The scientists were announced as this year’s recipients for their groundbreaking discoveries concerning peripheral immune tolerance that prevents the immune system from harming the body.
The laureates identified the immune system’s security guards, regulatory T cells, which prevent immune cells from attacking our own body.
“Their discoveries have been decisive for our understanding of how the immune system functions and why we do not all develop serious autoimmune diseases,” says Olle Kämpe, chair of the Nobel Committee.
According to a press release on Monday, it was disclosed that Shimon Sakaguchi was swimming against the tide in 1995, when he made the first key discovery. At the time, many researchers were convinced that immune tolerance only developed due to potentially harmful immune cells being eliminated in the thymus, through a process called central tolerance.
Sakaguchi showed that the immune system is more complex and discovered a previously unknown class of immune cells, which protect the body from autoimmune diseases.
Years later, Mary Brunkow and Fred Ramsdell made the other key discovery, when they presented the explanation for why a specific mouse strain was particularly vulnerable to autoimmune diseases.
The duo in 2001 discovered that the mice have a mutation in a gene that they named Foxp3. They also showed that mutations in the human equivalent of this gene cause a serious autoimmune disease, IPEX.
Two years after this, Shimon Sakaguchi was able to link these discoveries. He proved that the Foxp3 gene governs the development of the cells he identified in 1995. These cells, now known as regulatory T cells, monitor other immune cells and ensure that our immune system tolerates our own tissues.
The laureates’ discoveries launched the field of peripheral tolerance, spurring the development of medical treatments for cancer and autoimmune diseases.
This development holds many promises for the future of science as it may also lead to more successful transplantations. Several of these treatments are now undergoing clinical trials.