Oprah Winfrey’s massive weight loss since taking Ozempic, she’s now a size 4!
Media Take Out has learned that Oprah Winfrey is out here turning heads — and turning back the clock. The 70-year-old media mogul stunned the crowd yesterday at Ralph Lauren’s New York Fashion Week show, showing off her slimmest frame in decades.
According to insiders close to the queen of all media, Oprah has reportedly dropped a whopping 40 pounds — and is now wearing a size 4. That’s right, sis. Size. Four.
Back to Her Smallest Size Since the ’80s
Sources tell Media Take Out this is the lightest Oprah has been since her infamous 1980s “liquid crash diet” era, when she wheeled a wagon of fat onto her talk show stage to show off her massive weight loss.
The difference this time? She’s looking healthy, radiant, and confident — not drained and tired like before.
Ozempic Rumors Swirl
While Oprah herself hasn’t officially confirmed it, word in the industry is that her slim-down is connected to the Ozempic/Wegovy trend sweeping Hollywood. Our source explained:
“Everyone in her circle knows she’s on something like Ozempic. Oprah has tried everything over the years, but this time the results are insane. She’s kept it off and looks fabulous.”

Fashion Week Moment
At the Ralph Lauren show, Oprah stepped out in a chic, fitted ensemble that showed off her dramatically smaller waistline. Guests at the event were stunned — with more than a few whispering about how incredible she looked.
Paparazzi photos from the night are already making the rounds online, and fans can’t stop buzzing about her transformation. One fan tweeted: “Oprah is giving 1990s Oprah but snatched.”
The Reinvention Continues
Throughout her career, Oprah has been transparent about her struggles with food, dieting, and body image. But this latest reinvention may be her most dramatic yet. She’s looking not only slimmer, but also more stylish and rejuvenated than ever.
And knowing Oprah, this won’t just be a personal glow-up — it could signal the start of a new era for her brand. Fashion, lifestyle, health … maybe even another cover-shaking O Magazine moment?
One thing’s for sure: Oprah isn’t just back in the spotlight — she’s owning it.