Vanessa Williams Calls Mounjaro a “Game-Changer” — But Fans Are Also Noticing the So-Called “Ozempic Face” Effect
Vanessa Williams is being refreshingly honest about how she’s maintaining her stunning appearance at 62 — and it involves science, not secrets.
The actress and singer recently opened up about her weight-loss journey, revealing that she has been using Mounjaro (tirzepatide) for the past two years. As she graced the cover of Hello! Magazine, Vanessa described the medication as a “game-changer,” crediting it with helping her stay healthy, confident, and in control of her body as she ages.
“When I turned 60, I was like, ‘I want to be here for a long time, and I want to look my best,’” she shared. “My fifties were hard… suddenly, your body just doesn’t react the same way anymore.”
Vanessa explained that despite working out and eating well, menopause-related changes made it difficult to maintain her figure, which ultimately led her to explore medical options.
Science Over Struggle
Tirzepatide, the medication Vanessa referenced, is the active ingredient in Mounjaro, a GLP-1 drug widely used for weight loss. Vanessa also revealed she is on hormone replacement therapy (HRT) and has begun NAD+ injections, which are said to support cellular rejuvenation.
“Science is amazing,” she said. “I’m like, ‘What’s next? Bring it on!’”
The honesty has earned her praise from fans who appreciate celebrities being transparent about how they maintain their looks in an era where filters and vague “diet and exercise” claims are still the norm.
But Fans Are Also Noticing a Change
While many are applauding Vanessa’s confidence and candor, some fans have pointed out a visible shift in her facial appearance.
In recent photos, including her Hello! cover and red-carpet appearances, Vanessa appears to have a more drawn face, with wrinkles and facial lines more pronounced than in previous years. Online, some have linked the change to what has become known as “Ozempic face,” a term used to describe facial volume loss that can occur in people who experience rapid weight loss from GLP-1 medications.

Medical experts say that in non-obese individuals, these drugs can sometimes lead to loss of muscle and fat in the face, resulting in a leaner, more hollowed look. While the effect is not harmful, it can make aging appear more noticeable, particularly around the cheeks, eyes, and jawline.
A Trade-Off Many Are Willing to Make
For many women, especially those navigating menopause, the physical and emotional benefits of weight-loss medications outweigh aesthetic changes. Vanessa has made it clear that her goal is not perfection, but longevity, health, and self-confidence.
And despite the online chatter, she remains radiant, poised, and fully in control of her narrative.
Still Booked, Busy, and Unbothered
Beyond her wellness journey, Vanessa continues to thrive professionally. She recently addressed rumors surrounding a potential Desperate Housewives reboot, acknowledging that producers may be looking for a younger cast for the reimagined series, now titled Wisteria Lane. She also spoke about changes in the cast of her West End production of The Devil Wears Prada, expressing excitement for what lies ahead.
The Real Takeaway
Vanessa Williams is doing what many women are now choosing: using modern medicine to support their health while embracing the realities of aging.
Yes, some fans may notice changes in her face.
But what stands out even more is her confidence, transparency, and refusal to hide behind unrealistic beauty standards.
In an industry obsessed with youth, Vanessa is proving that evolving — even visibly — is not something to apologize for.
And honestly? That might be the most powerful glow-up of all.
